Cdock II and F1 and F2 I get F1 to load os or F2 to go to bios when i use the c dock II. C/Dock (1 PCI Slot w/ Adaptec AUA-4000A USB 2.0 Card) All non-required. Bring more power to your laptop. Surface Dock 2 transforms your Surface into a desktop PC with a 199W power supply to charge most Surface devices, plus USB-C®¹ ports that support dual 4K monitors at 60Hz. Simply plug in the Surface Connect cable to charge your device and access external monitors, a keyboard, mouse, and more.
Accurate binding mode prediction:
CovDock is built upon a foundation of the time-tested Glide docking algorithm and Prime structure refinement methodology for accurate prediction of non-covalently docked poses. Glide quickly samples a large pool of initial poses for the pre-reactive species and Prime simultaneously optimizes the ligand pose and attachment residue to produce a sound physical chemistry. The resultant accuracy outperforms other docking programs in achieving lower RMS deviations from native co-crystallized structures.
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Complete workflow:
CovDock performs a series of automated steps based on a simple setup from the Maestro graphical interface or from the command line. First, CovDock docks the pre-reactive ligand to determine viable poses that bring the reactive group into close proximity with the reactive receptor residue. Then the covalent bond is formed for the top scoring complex structures, the covalently attached ligand is sampled, and the complexes are scored using all-atom molecular mechanics with the OPLS force field and VSGB2.0 implicit solvent model.
Intuitive graphical interface:
Schrödinger’s intuitive graphical user interface, Maestro, provides easy-to-use panels for straightforward set-up of experiments, easy visualization, and efficient analysis of CovDock results.
Citations and Acknowledgements
Cdock II And F1 And F2 - Dell Community
ö Zhu, K.; Borrelli, K.W.; Greenwood, J.R.; Day, T.; Abel, R.; Farid, R.S.; Harder, E., 'Docking covalent inhibitors: A parameter free approach to pose prediction and scoring,' J. Chem. Inf. Model., 2014, 54, 1932−1940